GLP-1 ‘Maintenance Dosing’ Could Be the Key to Keeping Weight Off

Many people regain up to 60 percent of the weight they lost on a GLP-1 medication within a year after stopping the drug. That’s why a growing number of GLP-1 users are turning to so-called “maintenance dosing,” which typically involves taking the medication at a lower dose to keep the pounds off. Two new clinical trials suggest the strategy can be successful, whether that means switching to a lower-dose GLP-1 injection or pill.

GLP-1 ‘Maintenance Dosing’ Could Be the Key to Keeping Weight Off. Many people regain up to 60 percent of the weight they lost on a GLP-1 medication within a year after stopping the drug. That’s why a growing number of GLP-1 users are turning to so-called “maintenance dosing,” which typically involves taking the medication at a lower dose to keep the pounds off. Two new clinical trials suggest the strategy can be successful, whether that means switching to a lower-dose GLP-1 injection or pill. “However people get their weight down, the body will fight to get it back up,” says Richard Siegel, MD , endocrinologist at Tufts Medicine Weight + Wellness – Stoneham, in Massachusetts. “There is a strong likelihood that the weight will trend back up unless people take action. Maintenance dosing is a big part of the plan that needs to be put in pla...